Temperature abetted synthesis of novel magnesium stannate nanoparticles assisted for nanomolar level detection of hazardous flavonoid in biological samples

Abstract

Fabrication of temperature-influenced nanoparticles over the superficial region of glassy carbon electrode (GCE) stimulates the electrocatalytic activity owing to their morphology, defective sites, and higher active surface area, etc. In this regard, we have fabricated annealed magnesium stannate nanoparticles (Mg₂SnO₄ NPs) on GCE for nanomolar level detection of hazardous flavoring and pharmaceutical compound Rutin (RT). To analyze the impact of temperature, we have compared annealed Mg₂SnO₄ NPs with unannealed magnesium stannate hydrate (MgSnO₃·3H₂O) particles. The physicochemical properties of synthesized materials were characterized with different microscopic and spectroscopic techniques. From these studies, annealed Mg₂SnO₄ NPs formed purely without any flith and existence of water molecules as compared to unannealed MgSnO₃·3H₂O. Moreover as fabricated, Mg₂SnO₄ NPs/GCE outcomes with higher redox behavior compared to other electrodes in presence of RT at optimized working buffer (pH = 7.0). Interestingly, the electrode successfully established a dual wider linear response (0.062-34.8 & 34.8-346.8 µM) with a nanomolar detection limit (1 nM) and higher sensitivity. The practicability analysis of the proposed sensor also affords excellent selectivity, reproducibility, repeatability, reversibility, and storage stability. Furthermore, the real sample analysis was carried out in blood and orange samples fallout with better recovery results.

Keywords: Amperometric (i-t); Co-precipitated synthesis; Flavonoid; Mg(2)SnO(4) NPs; MgSnO(3)·3H(2)O; Redox behavior.