Critical-size Defect Augmentation Using Sintered and Non-Sintered Bovine Bone Matrix - An Experimental Controlled Study in Minipigs

Lara Schorn; Tim Fienitz; Francesco De Donno; Anja Sterner-Kock; Alexandra C Maul; Henrik Holtmann; Julian Lommen; Daniel Rothamel

doi:10.1016/j.joms.2021.03.025

Critical-size Defect Augmentation Using Sintered and Non-Sintered Bovine Bone Matrix - An Experimental Controlled Study in Minipigs

J Oral Maxillofac Surg. 2021 Sep;79(9):1866-1873. doi: 10.1016/j.joms.2021.03.025. Epub 2021 Apr 6.

Authors

Lara Schorn¹, Tim Fienitz², Francesco De Donno³, Anja Sterner-Kock⁴, Alexandra C Maul⁵, Henrik Holtmann⁶, Julian Lommen⁷, Daniel Rothamel⁸

Affiliations

¹ Resident, Department of Oral, Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf Düsseldorf, DE.
² Resident, Department of Oral, Maxillofacial and Facial Plastic Surgery, Evangelisches Krankenhaus Bethesda, Mönchengladbach, DE; Head of Department, Department of Oral, Maxillofacial and Facial Plastic Surgery, Evangelisches Krankenhaus Bethesda, Mönchengladbach, Germany and Professor, , University Hospital Düsseldorf, Düsseldorf,DE. Electronic address: Tim.Fienitz@mg.johanniter-kliniken.de.
³ Resident, Department of Oral, Maxillofacial and Facial Plastic Surgery, Evangelisches Krankenhaus Bethesda, Mönchengladbach, DE.
⁴ Professor, Head of Department, Center for Experimental Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, DE.
⁵ Head of Department, Center for Experimental Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, DE.
⁶ Consultant, Department of Oral, Maxillofacial and Facial Plastic Surgery, Evangelisches Krankenhaus Bethesda, Mönchengladbach,DE.
⁷ Resident, Department of Oral, Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf Düsseldorf,DE.
⁸ Head of Department, Department of Oral, Maxillofacial and Facial Plastic Surgery, Evangelisches Krankenhaus Bethesda, Mönchengladbach, Germany and Professor, , University Hospital Düsseldorf, Düsseldorf,DE.

PMID: 34051155
DOI: 10.1016/j.joms.2021.03.025

Abstract

Purpose: Xenogeneic bone substitute materials are often used for augmentation of larger bone defects. Purification methods for these materials vary, mainly in terms of temperature. The aim of this study was to determine in vivo how sintering affects quantitative and qualitative bone regeneration of 2 bovine augmentation materials.

Methods: A total of 56 critical size defects were set at the frontal bone of 14 domestic pigs (4 each) and filled randomly with either bovine, sintered hydroxyapatite (BO), bovine, non-sintered hydroxyapatite (BOS), local autologous bone (AB) or left empty. All defects were additionally covered with a collagen membrane. Specimens were harvested after 4 and 8 weeks and were evaluated histologically and histomorphometrically.

Results: Histologically new bone could be seen in every group. Significantly highest new bone formation was found in AB. No significant difference could be detected between BO and BOS.

Conclusions: According to the results of this study, sintered bone substitute material remains histologically distinguishable but does not affect quantitative and qualitative bone regeneration.

MeSH terms

Animals
Bone Matrix*
Bone Regeneration
Bone Substitutes*
Cattle
Research Design
Swine
Swine, Miniature

Substances

Bone Substitutes