Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry

Wen-An Wang; Nicolas Demaurex

doi:10.1007/978-3-030-67696-4_4

Proteins Interacting with STIM1 and Store-Operated Ca²⁺ Entry

Prog Mol Subcell Biol. 2021:59:51-97. doi: 10.1007/978-3-030-67696-4_4.

Authors

Wen-An Wang¹, Nicolas Demaurex²

Affiliations

¹ Department of Cellular Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
² Department of Cellular Physiology and Metabolism, University of Geneva, Geneva, Switzerland. nicolas.demaurex@unige.ch.

PMID: 34050862
DOI: 10.1007/978-3-030-67696-4_4

Abstract

The endoplasmic reticulum (ER) Ca²⁺ sensor stromal interaction molecule 1 (STIM1) interacts with ORAI Ca²⁺ channels at the plasma membrane to regulate immune and muscle cell function. The conformational changes underlying STIM1 activation, translocation, and ORAI1 trapping and gating, are stringently regulated by post-translational modifications and accessory proteins. Here, we review the recent progress in the identification and characterization of ER and cytosolic proteins interacting with STIM1 to control its activation and deactivation during store-operated Ca²⁺ entry (SOCE).

Keywords: Cell signaling; Endoplasmic reticulum; Immunity; Ion channels; Protein trafficking.

Publication types

Review

MeSH terms

Calcium / metabolism
Calcium Channels / genetics
Calcium Channels / metabolism
Calcium Signaling* / genetics
Membrane Proteins / genetics
ORAI1 Protein / genetics
Stromal Interaction Molecule 1 / genetics

Substances

Calcium Channels
Membrane Proteins
ORAI1 Protein
Stromal Interaction Molecule 1
Calcium