Neutralization Heterogeneity of UK and South African Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in BNT162b2-Vaccinated or Convalescent Coronavirus Disease 2019 (COVID-19) Healthcare Workers

Clin Infect Dis. 2022 Mar 1;74(4):707-710. doi: 10.1093/cid/ciab492.

Abstract

There are concerns about neutralizing antibodies' (NAbs') potency against severe acute respiratory syndrome coronavirus 2 variants. Despite decreased NAb titers elicited by BNT162b2 vaccine against VOC202012/01 and 501Y.V2 strains, 28/29 healthcare workers (HCWs) had an NAb titer ≥1:10. In contrast, 6 months after coronavirus disease 2019 mild forms, only 9/15 (60%) of HCWs displayed detectable NAbs against 501Y.V2 strain.

Keywords: COVID-19; SARS-CoV-2 variants; neutralizing antibodies; vaccine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • BNT162 Vaccine
  • COVID-19*
  • Health Personnel
  • Humans
  • SARS-CoV-2 / genetics
  • United Kingdom / epidemiology

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • BNT162 Vaccine

Supplementary concepts

  • SARS-CoV-2 variants