ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update

Robin Lovell-Badge; Eric Anthony; Roger A Barker; Tania Bubela; Ali H Brivanlou; Melissa Carpenter; R Alta Charo; Amander Clark; Ellen Clayton; Yali Cong; George Q Daley; Jianping Fu; Misao Fujita; Andy Greenfield; Steve A Goldman; Lori Hill; Insoo Hyun; Rosario Isasi; Jeffrey Kahn; Kazuto Kato; Jin-Soo Kim; Jonathan Kimmelman; Jürgen A Knoblich; Debra Mathews; Nuria Montserrat; Jack Mosher; Megan Munsie; Hiromitsu Nakauchi; Luigi Naldini; Gail Naughton; Kathy Niakan; Ubaka Ogbogu; Roger Pedersen; Nicolas Rivron; Heather Rooke; Janet Rossant; Jeff Round; Mitinori Saitou; Douglas Sipp; Julie Steffann; Jeremy Sugarman; Azim Surani; Jun Takahashi; Fuchou Tang; Leigh Turner; Patricia J Zettler; Xiaomei Zhai

doi:10.1016/j.stemcr.2021.05.012

ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update

Stem Cell Reports. 2021 Jun 8;16(6):1398-1408. doi: 10.1016/j.stemcr.2021.05.012. Epub 2021 May 27.

Authors

Robin Lovell-Badge¹, Eric Anthony², Roger A Barker³, Tania Bubela⁴, Ali H Brivanlou⁵, Melissa Carpenter⁶, R Alta Charo⁷, Amander Clark⁸, Ellen Clayton⁹, Yali Cong¹⁰, George Q Daley¹¹, Jianping Fu¹², Misao Fujita¹³, Andy Greenfield¹⁴, Steve A Goldman¹⁵, Lori Hill¹⁶, Insoo Hyun¹⁷, Rosario Isasi¹⁸, Jeffrey Kahn¹⁹, Kazuto Kato²⁰, Jin-Soo Kim²¹, Jonathan Kimmelman²², Jürgen A Knoblich²³, Debra Mathews¹⁹, Nuria Montserrat²⁴, Jack Mosher², Megan Munsie²⁵, Hiromitsu Nakauchi²⁶, Luigi Naldini²⁷, Gail Naughton²⁸, Kathy Niakan²⁹, Ubaka Ogbogu³⁰, Roger Pedersen³¹, Nicolas Rivron²³, Heather Rooke³², Janet Rossant³³, Jeff Round³⁴, Mitinori Saitou¹³, Douglas Sipp³⁵, Julie Steffann³⁶, Jeremy Sugarman¹⁹, Azim Surani³⁷, Jun Takahashi¹³, Fuchou Tang¹⁰, Leigh Turner³⁸, Patricia J Zettler³⁹, Xiaomei Zhai⁴⁰

Affiliations

¹ Francis Crick Institute, London, UK. Electronic address: robin.lovell-badge@crick.ac.uk.
² International Society for Stem Cell Research, Skokie, IL, USA.
³ Cambridge Center for Brain Repair and WT-MRC Stem Cell Institute, Cambridge, UK.
⁴ Simon Fraser University, Burnaby, BC, Canada.
⁵ The Rockefeller University, New York, NY, USA.
⁶ ElevateBio/Carpenter Group Consulting, Waltham, MA, USA.
⁷ University of Wisconsin-Madison, Madison, WI, USA.
⁸ University of California, Los Angeles, Los Angeles, CA, USA.
⁹ Vanderbilt University, Nashville, TN, USA.
¹⁰ Peking University, Beijing, China.
¹¹ Harvard Medical School, Boston, MA, USA.
¹² University of Michigan, Ann Arbor, MI USA.
¹³ Kyoto University, Kyoto, Japan.
¹⁴ MRC Harwell Institute, Oxfordshire, UK.
¹⁵ University of Rochester Medical Center, Rochester, NY, USA; University of Copenhagen, Copenhagen, Denmark.
¹⁶ MD Anderson, Houston, TX, USA.
¹⁷ Harvard Medical School, Boston, MA, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
¹⁸ University of Miami, Coral Gables, FL, USA.
¹⁹ Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.
²⁰ Osaka University, Suita, Japan.
²¹ Seoul National University, Seoul, Korea.
²² McGill University, Montreal, QC, Canada.
²³ IMBA-Institute of Molecular Biotechnology, Vienna, Austria.
²⁴ Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain.
²⁵ University of Melbourne, Melbourne, VIC, Australia.
²⁶ Stanford University, Stanford, CA, USA; University of Tokyo, Tokyo, Japan.
²⁷ Università Vita-Salute San Raffaele, Milan, Italy.
²⁸ Histogen, San Diego, CA, USA.
²⁹ Francis Crick Institute, London, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.
³⁰ University of Alberta, Edmonton, AB, Canada.
³¹ Stanford University, Stanford, CA, USA.
³² Broad Institute, Cambridge, MA, USA.
³³ Gairdner Foundation/SickKids, Toronto, ON, Canada.
³⁴ Institute of Health Economics, Edmonton, AB, Canada.
³⁵ RIKEN Center for Developmental Biology, Wako, Japan; Keio University School of Medicine, Tokyo, Japan.
³⁶ Université Paris Descartes, Paris, France.
³⁷ Gurdon Institute, University of Cambridge, Cambridge, UK.
³⁸ University of Minnesota, Minneapolis, MN, USA.
³⁹ Ohio State University, Columbus, OH, USA.
⁴⁰ Peking Union Medical College, Beijing, China.

Abstract

The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social, and policy issues that have arisen since the last update in 2016. While growing to encompass the evolving science, clinical applications of stem cells, and the increasingly complex implications of stem cell research for society, the basic principles underlying the Guidelines remain unchanged, and they will continue to serve as the standard for the field and as a resource for scientists, regulators, funders, physicians, and members of the public, including patients. A summary of the key updates and issues is presented here.

Publication types

Review

MeSH terms

Bioethical Issues / standards*
Humans
Policy*
Practice Guidelines as Topic*
Societies, Scientific / ethics
Societies, Scientific / standards*
Stem Cell Research / ethics*
Stem Cells*

Abstract

Publication types

MeSH terms

Grants and funding