Abstract
Existing evidence revealed grave prognosis for cryptococcal meningitis (CM), particularly its short-term mortality. However, its long-term survival and prognostic factors remained unknown. This study investigated 3-year mortality and analyzed its predictive factors in patients with CM. This retrospective cohort study with 83 cerebrospinal fluid culture-confirmed CM patients was conducted at China Medical University Hospital from 2003 to 2016. The 3-year mortality rate in patients with CM was 54% (45 deaths among 83 patients). Advanced age, human immunodeficiency virus (HIV) seronegative state, low Glasgow Coma Scale score on admission, decreased hemoglobin and hyperglycemia on diagnosis were associated with 3-year mortality. After multivariate adjustment in the Cox proportional hazard model, only severe hyperglycemia (serum glucose ≥200 mg/dL) on diagnosis could predict 3-year mortality.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Age Factors
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Aged
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Cryptococcus neoformans / immunology
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Cryptococcus neoformans / isolation & purification
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Female
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Follow-Up Studies
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Glasgow Coma Scale
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HIV Seronegativity / immunology*
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Humans
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Hyperglycemia / diagnosis
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Hyperglycemia / epidemiology*
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Hyperglycemia / immunology
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Hyperglycemia / microbiology
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Male
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Meningitis, Cryptococcal / complications
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Meningitis, Cryptococcal / diagnosis
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Meningitis, Cryptococcal / immunology
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Meningitis, Cryptococcal / mortality*
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Middle Aged
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Prognosis
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Retrospective Studies
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Risk Assessment / methods
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Risk Assessment / statistics & numerical data
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Risk Factors
Grants and funding
This study was supported by grants from the Ministry of Science and Technology, Taiwan (Grant number: MOST 108-2314-B-039-038-MY3 and MOST 109-2321-B-468- 001) and from CMUH (DMR-109-130). This study was not sponsored by industry. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.