Functions and Targets of miR-335 in Cancer

Lingling Ye; Fen Wang; Hao Wu; Hui Yang; Yan Yang; Yajun Ma; Aili Xue; Jing Zhu; Meili Chen; Jinyan Wang; Quan An Zhang

doi:10.2147/OTT.S305098

Functions and Targets of miR-335 in Cancer

Onco Targets Ther. 2021 May 20:14:3335-3349. doi: 10.2147/OTT.S305098. eCollection 2021.

Authors

Lingling Ye¹, Fen Wang¹, Hao Wu¹, Hui Yang¹, Yan Yang¹, Yajun Ma¹, Aili Xue¹, Jing Zhu¹, Meili Chen¹, Jinyan Wang¹, Quan An Zhang¹

Affiliation

¹ Department of Oncology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs (18~25 nt in length) that act as master regulators of eukaryotic gene expression. They might play an oncogenic or tumor-suppressive role in multiple cancers. In recent decades, several studies have focused on the functions and mechanisms of miR-335 in cancer. The expression level of miR-335 in tissues and cells varies with cancer types, and miR-335 has been proposed as a potential biomarker for the prognosis of cancer. Besides, miR-335 may serve as an oncogene or tumor suppressor via regulating different targets or pathways in tumor initiation, development, and metastasis. Furthermore, miR-335 also inﬂuences tumor microenvironment and drug sensitivity. MiR-335 is regulated by various factors such as lncRNAs and microRNAs. In this review, we reveal the functions and targets of miR-335 in various cancers and its potential application as a possible biomarker in prognostic judgment and treatment of malignant tumors.

Keywords: miR-335 cancer; prognosis; regulation; tumor biology.

Publication types

Review

Grants and funding

This research was funded by the Natural Science Foundation of Jiangsu Province (grant number BK20161110), Key project of Nanjing Science and Technology Plan (grant number ZKX14030), Medical Research Grant of Jiangsu Commission of Health (grant number M2020010), the Science Foundation of Jiangsu Health vocational college (grant number JKC201948), the Science and Technology Development Fund of Nanjing Medical University (grant number NMUB2019235), the Nanjing health science and Technology Development Fund (grant number YKK18201), Science and technology development fund of Nanjing Medical University (grant number 2017NJMUZD091) and the Research and development fund of Kangda College of Nanjing Medical University (grant number KD2017KYJJYB017, KD2020KYJJZD006).