Dentipellin, a new antibiotic from culture broth of Dentipellis fragilis

J Antibiot (Tokyo). 2021 Aug;74(8):538-541. doi: 10.1038/s41429-021-00426-1. Epub 2021 May 27.

Abstract

In our effort to find antimicrobial agents from higher fungi, we isolated a new compound, dentipellin (1), along with three known glycosylated diterpenes, erinacines A-C (2-4) from culture broth of Dentipellis fragilis. Their chemical structures were determined by spectroscopic methods including NMR and mass measurements. These compounds exhibited weak antibacterial and antifungal activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Bacteria / drug effects
  • Basidiomycota / chemistry*
  • Culture Media
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Fungi / drug effects
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Conformation

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Culture Media
  • Diterpenes

Supplementary concepts

  • Dentipellis fragilis