Generation Z is entering the workforce, requiring nursing professional development (NPD) practitioners to consider their unique characteristics when planning ongoing professional learning. They are also entering the profession at a time when concerns for well-being and resilience are at an all-time high. This article compares psychological capital scores between generational cohorts and provides strategies for the NPD practitioner with the development and education of Generation Z nurses. [J Contin Educ Nurs. 2021;52(4):160-162.].