Where are the RNA vaccines for TB?

Xiao-Yong Fan; Douglas Bruce Lowrie

doi:10.1080/22221751.2021.1935328

Where are the RNA vaccines for TB?

Emerg Microbes Infect. 2021 Dec;10(1):1217-1218. doi: 10.1080/22221751.2021.1935328.

Authors

Xiao-Yong Fan¹, Douglas Bruce Lowrie¹

Affiliation

¹ TB Center, Shanghai Emerging and Re-emerging Institute, Shanghai Public Health Clinical Center and Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai, People's Republic of China.

Abstract

A simple mRNA vaccine was shown to protect mice against tuberculosis more than 15 years ago. Like COVID-19, tuberculosis is a respiratory infection killing over a million people per year. It too presents a global emergency. Can the stunning success of RNA vaccination against COVID-19 be replicated for TB?

Keywords: COVID-19; RNA vaccination; Tuberculosis; in vitro transcription; vaccine.

MeSH terms

Humans
Tuberculosis / immunology
Tuberculosis / microbiology
Tuberculosis / prevention & control*
Tuberculosis Vaccines / immunology*
Vaccines, Synthetic / immunology*
mRNA Vaccines

Substances

Tuberculosis Vaccines
Vaccines, Synthetic

Grants and funding

We thank Chinese National Mega Science and Technology Program on Infectious Diseases [grant number 2018ZX10302301,2018ZX10731301], National Natural Science Foundation of China [grant number 31771004], Shanghai Science and Technology Commission [grant number 19XD1403100, 20Y11903400], Shanghai Public Health Clinical Center.