68Ga-FAPI PET/CT Versus 18F-FDG PET/CT for Detecting Metastatic Lesions in a Case of Radioiodine-Refractory Differentiated Thyroid Cancer

Clin Nucl Med. 2021 Nov 1;46(11):940-942. doi: 10.1097/RLU.0000000000003730.

Abstract

18F-FDG PET/CT is a useful imaging modality for detecting disease recurrence and metastases in patients with radioiodine-refractory differentiated thyroid cancer (RAIR-DTC). However, the sensitivity of 18F-FDG PET/CT in RAIR-DTC is not very satisfactory. 68Ga-FAPI is a promising PET tracer that allowed imaging of various types of cancer. In this case, 68Ga-FAPI showed a far better signal-to-background ratio than 18F-FDG for detecting the RAIR-DTC metastatic lesions, especially for detecting the small pulmonary metastases. Therefore, 68Ga-FAPI may be a promising alternative to 18F-FDG for detecting tumor recurrence and metastases in RAIR-DTC. It could also be used for guiding FAP-targeted radionuclide therapy.

Publication types

  • Case Reports

MeSH terms

  • Fluorodeoxyglucose F18
  • Humans
  • Iodine Radioisotopes / therapeutic use
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / radiotherapy
  • Positron Emission Tomography Computed Tomography*
  • Quinolines
  • Thyroid Neoplasms* / diagnostic imaging
  • Thyroid Neoplasms* / radiotherapy

Substances

  • 68Ga-FAPI
  • Iodine Radioisotopes
  • Quinolines
  • Fluorodeoxyglucose F18