Effects of diabetes on the development of radiation pneumonitis

Respir Res. 2021 May 24;22(1):160. doi: 10.1186/s12931-021-01754-4.

Abstract

Radiation pneumonia (RP) is a common adverse reaction to radiation therapy in patients with chest tumors. Recent studies have shown that diabetes mellitus (DM), which can cause systemic multisystem damage, specifically targets lungs, and the incidence of RP in patients with a history of diabetes is higher than that in other patients with tumors who have undergone radiotherapy. DM is an important risk factor for RP in tumor patients undergoing RT, and patients with DM should be treated with caution. This article reviews research on the clinical aspects, as well as the mechanism, of the effects of diabetes on RP and suggests future research needed to reduce RP.

Keywords: Diabetes; Influence factors; Radiation pneumonia; Radiation therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / epidemiology*
  • Diabetes Mellitus / immunology
  • Diabetes Mellitus / metabolism
  • Humans
  • Incidence
  • Inflammation Mediators / metabolism
  • Neoplasms / epidemiology
  • Neoplasms / radiotherapy*
  • Oxidative Stress
  • Prognosis
  • Radiation Pneumonitis / epidemiology*
  • Radiation Pneumonitis / immunology
  • Radiation Pneumonitis / metabolism
  • Reactive Oxygen Species / metabolism
  • Risk Assessment
  • Risk Factors

Substances

  • Inflammation Mediators
  • Reactive Oxygen Species