Photobiomodulation induces murine macrophages polarization toward M2 phenotype

Valdison P Reis; Mauro V Paloschi; Cristina M A Rego; Maria Naiara M Tavares; Charles N Boeno; Jéssica A Lopes; Alex A Ferreira E Ferreira; Andreimar M Soares; Stella R Zamuner; Juliana P Zuliani

doi:10.1016/j.toxicon.2021.05.009

Photobiomodulation induces murine macrophages polarization toward M2 phenotype

Toxicon. 2021 Jul 30:198:171-175. doi: 10.1016/j.toxicon.2021.05.009. Epub 2021 May 21.

Affiliations

¹ Lab. Imunologia Cellular Aplicada à Saúde, FIOCRUZ-Rondônia, Porto Velho, RO, Brazil.
² Centro de Estudos de Biomoléculas Aplicadas à Saúde, CEBio, Dep. Medicina, Universidade Federal de Rondônia, UNIR e FIOCRUZ-Rondônia, Porto Velho, RO, Brazil; Centro Universitário São Lucas, UNISL, Porto Velho, RO, Brazil.
³ Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.
⁴ Lab. Imunologia Cellular Aplicada à Saúde, FIOCRUZ-Rondônia, Porto Velho, RO, Brazil; Centro de Estudos de Biomoléculas Aplicadas à Saúde, CEBio, Dep. Medicina, Universidade Federal de Rondônia, UNIR e FIOCRUZ-Rondônia, Porto Velho, RO, Brazil. Electronic address: juliana.zuliani@fiocruz.br.

PMID: 34029603
DOI: 10.1016/j.toxicon.2021.05.009

Abstract

Photobiomodulation using light-emitting diode (LED) treatment has analgesic and anti-inflammatory effects which can be an effective therapeutic associated with serum therapy for local treatment of snakebites. Here we explored the effects of LED treatment on isolated macrophage under Bothrops jararacussu venom. Results showed that LED induced IL-6 and TNF-α genes down-regulation and, TGF and ARG1 genes up-regulation which indicates a polarization of macrophages to an M2 phenotype contributing to both tissue repair and resolution of inflammation.

Keywords: Bothrops jararacussu venom; Light emitting diode; Macrophages; Photobiomodulation.

MeSH terms

Animals
Bothrops*
Crotalid Venoms*
Low-Level Light Therapy*
Macrophages
Mice
Phenotype

Substances

Crotalid Venoms