Positive Somatostatin Receptor Expression Demonstrated on 68Ga-NODAGA-LM3 PET/CT in a Neuroendocrine Tumor Patient With Negative Immunohistochemical Staining: Conflict or Heterogeneity

Clin Nucl Med. 2021 Sep 1;46(9):750-751. doi: 10.1097/RLU.0000000000003653.

Abstract

We present a case with pulmonary atypical carcinoid and multiple hepatic metastases. Immunohistochemical staining of liver biopsy sample was negative for somatostatin receptor subtype 2, but 68Ga-NODAGA-LM3 PET/CT scan revealed multiple positive lesions. The mismatch was actually caused by heterogeneous expression of somatostatin receptor in liver lesions.

Publication types

  • Case Reports

MeSH terms

  • Acetates
  • Heterocyclic Compounds, 1-Ring
  • Humans
  • Neuroendocrine Tumors* / diagnostic imaging
  • Organometallic Compounds*
  • Positron Emission Tomography Computed Tomography
  • Receptors, Somatostatin
  • Somatostatin
  • Staining and Labeling

Substances

  • 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane
  • Acetates
  • Heterocyclic Compounds, 1-Ring
  • Organometallic Compounds
  • Receptors, Somatostatin
  • Somatostatin