Dissociated response related to corticosteroids in lung cancer treated by immunotherapy: A case report

Quentin Dominique Thomas; Léa Sinoquet; Antonio Maraver; Xavier Quantin

doi:10.1002/ccr3.3973

Dissociated response related to corticosteroids in lung cancer treated by immunotherapy: A case report

Clin Case Rep. 2021 Mar 24;9(5):e03973. doi: 10.1002/ccr3.3973. eCollection 2021 May.

Authors

Quentin Dominique Thomas^{1

2}, Léa Sinoquet¹, Antonio Maraver², Xavier Quantin^{1

2}

Affiliations

¹ Service d'Oncologie Médicale Institut du Cancer de Montpellier (ICM) Université de Montpellier Montpellier France.
² Institut de Recherche en Cancérologie de Montpellier (IRCM) Montpellier France.

Abstract

We report the case of a patient with a complete metastatic adrenal response on Pembrolizumab for metastatic lung cancer. Treatment with a systemic corticosteroid-induced a time-dependent progression at his metastatic site. Surprisingly, after stopping the corticosteroid, we observed a new complete response in long-term adrenal metastases.

Keywords: case reports; immunotherapy; lung neoplasms; programmed cell death 1 receptor; tumor escape.

Publication types

Case Reports