Evaluation of pheniramine maleate and zofenopril in reducing renal damage induced by unilateral ureter obstruction. An experimental study

Ercan Yuvanc; Devrim Tuglu; Tunc Ozan; Ucler Kisa; Mahi Balci; Ertan Batislam; Erdal Yilmaz

doi:10.5114/aoms.2019.88320

Evaluation of pheniramine maleate and zofenopril in reducing renal damage induced by unilateral ureter obstruction. An experimental study

Arch Med Sci. 2019 Oct 4;17(3):812-817. doi: 10.5114/aoms.2019.88320. eCollection 2021.

Authors

Ercan Yuvanc¹, Devrim Tuglu¹, Tunc Ozan², Ucler Kisa³, Mahi Balci⁴, Ertan Batislam¹, Erdal Yilmaz¹

Affiliations

¹ Department of Urology, Kirikkale University School of Medicine, Kirikkale, Turkey.
² Department of Urology, Firat University School of Medicine, Elazig, Turkey.
³ Department of Biochemistry, Kirikkale University School of Medicine, Kirikkale, Turkey.
⁴ Department of Pathology, Kirikkale University School of Medicine, Kirikkale, Turkey.

Abstract

Introduction: Obstruction of the ureter may occur due to congenital, iatrogenic or other reasons. This can cause hydronephrosis in the early stage and can lead to cellular inflammation, necrosis and atrophy in the kidney tissue. The aim of this paper is to evaluate the protective effect of pheniramine maleate (PM) and zofenopril on renal damage caused by hydronephrosis due to unilateral partial ureter obstruction.

Material and methods: Twenty-four female Sprague Dawley rats were divided into 4 groups. Group 1: sham group, group 2: partial unilateral ureteral obstruction (PUUO) group, group 3: PUUO + PM group, group 4: PUUO + zofenopril group. Paraoxonase (PON), total antioxidant status (TAS) and total oxidant status (TOS) of tissue and blood samples were measured and calculated. Tissue samples were evaluated histopathologically.

Results: An increase in tissue TAS and a decrease in tissue TOS and OSI levels were detected in groups 3 and 4 compared to group 2 (both: p < 0.01). Tissue PON levels showed an increase in groups 3 and 4 compared to groups 1 and 2 (both: p < 0.01). Histopathological evaluation showed a decrease in interstitial inflammation and congestion in groups 3 and 4 compared to the control group (p < 0.001). The decrease was observed to be more significant in group 4 compared to group 3 (p < 0.01).

Conclusions: In our experimental study, we observed that PM and zofenopril reduce the oxidation and tissue damage caused by unilateral partial obstruction.

Keywords: hydronephrosis; kidney; oxidative stress index; paraoxonase; partial unilateral ureter obstruction; pheniramine maleate; total antioxidant capacity; total oxidant status; zofenopril.