Pyrimido[1,2- a]benzimidazoles: synthesis and perspective of their pharmacological use

Victor V Fedotov; Vladimir L Rusinov; Evgeny N Ulomsky; Evgeny M Mukhin; Evgeny B Gorbunov; Oleg N Chupakhin

doi:10.1007/s10593-021-02916-4

Pyrimido[1,2- a]benzimidazoles: synthesis and perspective of their pharmacological use

Chem Heterocycl Compd (N Y). 2021;57(4):383-409. doi: 10.1007/s10593-021-02916-4. Epub 2021 May 15.

Authors

Victor V Fedotov¹, Vladimir L Rusinov^{1

2}, Evgeny N Ulomsky^{1

2}, Evgeny M Mukhin¹, Evgeny B Gorbunov², Oleg N Chupakhin^{1

2}

Affiliations

¹ Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St, Yekaterinburg, 620002 Russia.
² Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St, Yekaterinburg, 620108 Russia.

Abstract

The review presents data on the synthesis as well as studies of biological activity of new derivatives of pyrimido[1,2-a]benzimidazoles published over the last decade. The bibliography of the review includes 136 sources.

Keywords: 2-aminobenzimidazole; heterocyclization; multicomponent reactions; polynitrogen-containing heteroarenes; pyrimido[1,2-a]benzimidazoles.