Mutagenesis of the Cleavage Site of Pro Renin Receptor Abrogates Angiotensin II-Induced Hypertension in Mice

Hypertension. 2021 Jul;78(1):115-127. doi: 10.1161/HYPERTENSIONAHA.121.16770. Epub 2021 May 24.

Abstract

[Figure: see text].

Keywords: angiotensin II; hypertension; renin-angiotensin system site-1 protease; soluble (pro)renin receptor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Angiotensin II
  • Animals
  • Base Sequence
  • Binding Sites / genetics
  • Blood Pressure / drug effects
  • Blood Pressure / genetics
  • Blood Pressure / physiology
  • CRISPR-Cas Systems
  • Cells, Cultured
  • Hypertension / chemically induced
  • Hypertension / genetics
  • Hypertension / physiopathology*
  • Mice
  • Mice, Knockout
  • Mutagenesis
  • Protein Precursors / genetics
  • Protein Precursors / metabolism*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Renin / genetics
  • Renin / metabolism*
  • Renin-Angiotensin System / drug effects
  • Renin-Angiotensin System / genetics
  • Renin-Angiotensin System / physiology

Substances

  • Protein Precursors
  • Receptors, Cell Surface
  • Angiotensin II
  • Renin