Update on Cutaneous Soft Tissue Tumors

Josephine K Dermawan; Jennifer S Ko; Steven D Billings

doi:10.1016/j.path.2021.03.002

Update on Cutaneous Soft Tissue Tumors

Surg Pathol Clin. 2021 Jun;14(2):195-207. doi: 10.1016/j.path.2021.03.002.

Authors

Josephine K Dermawan¹, Jennifer S Ko², Steven D Billings³

Affiliations

¹ Soft Tissue and Bone Pathology Section, Department of Pathology, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA.
² Dermatopathology Section, Department of Pathology, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA.
³ Dermatopathology Section, Department of Pathology, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA. Electronic address: billins@ccf.org.

PMID: 34023100
DOI: 10.1016/j.path.2021.03.002

Abstract

This article focuses on various recently described or emerging cutaneous soft tissue neoplasms. These entities encompass a wide range of clinical and histologic characteristics. Emphasis is placed on their distinguishing morphologic and immunophenotypic features compared with entities that enter into their differential diagnosis, as well as novel immunophenotypic and molecular tests that are often necessary for accurate diagnosis of these entities. Entities discussed include EWSR1-SMAD3-rearranged fibroblastic tumor, superficial CD34-positive fibroblastic tumor, epithelioid fibrous histiocytoma, CIC-rearranged sarcomas, and NTRK-rearranged spindle cell tumors.

Keywords: CIC-rearranged sarcoma; EWSR1-SMAD3-rearranged fibroblastic tumor; Epithelioid fibrous histiocytoma; NTRK-rearranged spindle cell neoplasm; Superficial CD34-positive fibroblastic tumor.

Publication types

Review

MeSH terms

Biomarkers, Tumor / genetics
Diagnosis, Differential
Humans
Immunophenotyping
Sarcoma, Small Cell*
Soft Tissue Neoplasms* / diagnosis
Soft Tissue Neoplasms* / genetics

Substances

Biomarkers, Tumor