Quantification of Regional Cerebral Blood Flow Using Diffusion Imaging With Phase Contrast

Abstract

Background: The perfusion-related diffusion coefficient obtained from triexponential diffusion analysis is closely correlated with regional cerebral blood flow (rCBF), as assessed by arterial spin labeling (ASL) methods. However, this provides only a semiquantitative measure of rCBF, thereby making absolute rCBF quantification challenging.

Purpose: To obtain rCBF in a noninvasive manner using a novel diffusion imaging method with phase contrast (DPC), in which the total CBF from phase-contrast (PC) MRI was utilized to convert perfusion-related diffusion coefficients to rCBF values.

Study type: Prospective.

Subjects: Eleven healthy volunteers (nine men and two women; mean age, 23.9 years) participated in this study.

Field strength/sequence: A 3.0 T, single-shot diffusion echo-planar imaging with multiple b-values (0-3000 s/mm² ), PC-MRI, pulsed continuous ASL, and 3D T₁ -weighted fast field echo.

Assessment: rCBF and its correlations in the gray matter (GM) and white matter (WM) were compared between DPC and ASL methods. rCBF in the GM and WM and the GM/WM ratio were compared with the literature values obtained using [¹⁵ O]-water positron emission tomography (¹⁵ O-H₂ O PET).

Statistical tests: Spearman's correlation coefficient and Wilcoxon signed-rank test were used. Significance was set at P < 0.05.

Results: A significant positive correlation between DPC and ASL in terms of rCBF was observed in GM (R = 0.9), whereas the correlation between the two methods was poor in WM (R = 0.09). The rCBF in GM and WM and the GM/WM ratio obtained using DPC were consistent with the literature values assessed using ¹⁵ O-H₂ O PET. The rCBF value obtained using DPC was significantly higher in the GM and WM than that using ASL.

Data conclusion: DPC enabled noninvasive quantification of rCBF.

Evidence level: 2 TECHNICAL EFFICACY: Stage 1.

Keywords: cerebral blood flow; diffusion-weighted imaging; intravoxel incoherent motion; perfusion-related diffusion; phase contrast.