Two new dipimprinine alkaloids from soil-derived Streptomyces sp. 44414B

J Antibiot (Tokyo). 2021 Jul;74(7):474-476. doi: 10.1038/s41429-021-00424-3. Epub 2021 May 21.

Abstract

Two new dipimprinine alkaloids dipimprinine E (1) and dipimprinine F (2) were isolated from Streptomyces sp. 44414B. The structure was elucidated by extensive spectroscopic analysis, including ESI-MS, HR-MS, and 1D and 2D NMR experiments. Dipimprinines F (2) showed cytotoxic activities against three tumor cell lines, including A-875, Hep G2, and H-460, with IC50 values of 26.4, 0.5, and 9.0 μg ml-1, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Hep G2 Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Oxazoles / chemistry
  • Soil Microbiology
  • Spectrometry, Mass, Electrospray Ionization
  • Streptomyces / chemistry*
  • Streptomyces / isolation & purification

Substances

  • Alkaloids
  • Antineoplastic Agents
  • Oxazoles
  • pimprinine