Abstract
Two new dipimprinine alkaloids dipimprinine E (1) and dipimprinine F (2) were isolated from Streptomyces sp. 44414B. The structure was elucidated by extensive spectroscopic analysis, including ESI-MS, HR-MS, and 1D and 2D NMR experiments. Dipimprinines F (2) showed cytotoxic activities against three tumor cell lines, including A-875, Hep G2, and H-460, with IC50 values of 26.4, 0.5, and 9.0 μg ml-1, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Hep G2 Cells
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Oxazoles / chemistry
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Soil Microbiology
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Spectrometry, Mass, Electrospray Ionization
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Streptomyces / chemistry*
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Streptomyces / isolation & purification
Substances
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Alkaloids
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Antineoplastic Agents
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Oxazoles
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pimprinine