Case of Kikuchi-Fujimoto disease associated with multiple myeloma

Luqman Safwan Fauzi; Vidhi Unadkat; Siti Nadhirah Binti Abd Hadi; Ciro Rinaldi

doi:10.1136/bcr-2020-241391

Case of Kikuchi-Fujimoto disease associated with multiple myeloma

BMJ Case Rep. 2021 May 20;14(5):e241391. doi: 10.1136/bcr-2020-241391.

Authors

Luqman Safwan Fauzi¹, Vidhi Unadkat², Siti Nadhirah Binti Abd Hadi³, Ciro Rinaldi³

Affiliations

¹ Internal Medicine, Pilgrim Hospital, Boston, Lincolnshire, UK luqman.fauzi@doctors.org.uk.
² Internal Medicine, Pilgrim Hospital, Boston, Lincolnshire, UK.
³ Department of Haematology, Pilgrim Hospital, Boston, Lincolnshire, UK.

Abstract

We present a 47-year-old, South-African origin, woman with a background of stable monoclonal gammopathy of unknown significance (MGUS) who attended A&E with a history of coryzal symptoms associated with persistent fever, lymphadenopathy and a new onset of rash, not responding to antibiotics and paracetamol. A trial of high-dose steroids resolved symptoms. Bone marrow biopsy confirmed a progression of MGUS into multiple myeloma and her axillary lymph node biopsy analysis supported a diagnosis of Kikuchi-Fujimoto disease (KFD). This is an unusual presentation where KFD has been noted alongside MGUS progression to multiple myeloma. Haematology follow-up is underway.

Keywords: malignant and benign haematology; medical management; monoclonal gammopathy of undetermined significance associated neuropathy; pathology.

Publication types

Case Reports

MeSH terms

Biopsy
Female
Histiocytic Necrotizing Lymphadenitis* / complications
Histiocytic Necrotizing Lymphadenitis* / diagnosis
Histiocytic Necrotizing Lymphadenitis* / drug therapy
Humans
Lymphadenopathy*
Middle Aged
Monoclonal Gammopathy of Undetermined Significance*
Multiple Myeloma* / complications
Multiple Myeloma* / diagnosis
Multiple Myeloma* / drug therapy