Antibiotic Utilization in Deceased Organ Donors

Judith A Anesi; Ebbing Lautenbach; Jennifer Han; Dong Heun Lee; Heather Clauss; Antonette Climaco; Richard Hasz; Warren B Bilker; Esther Molnar; Darcy Alimenti; Sharon West; Pam Tolomeo; Emily A Blumberg

doi:10.1093/cid/ciab463

Antibiotic Utilization in Deceased Organ Donors

Clin Infect Dis. 2021 Oct 5;73(7):1284-1287. doi: 10.1093/cid/ciab463.

Authors

Judith A Anesi^{1

2

3}, Ebbing Lautenbach^{1

2

3}, Jennifer Han⁴, Dong Heun Lee⁵, Heather Clauss⁶, Antonette Climaco⁷, Richard Hasz⁸, Warren B Bilker^{2

3}, Esther Molnar⁶, Darcy Alimenti^{1

2}, Sharon West⁸, Pam Tolomeo^{2

3}, Emily A Blumberg¹

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
² Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
³ Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁴ GlaxoSmithKline, Rockville, Maryland, USA.
⁵ Division of Infectious Diseases, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
⁶ Section of Infectious Diseases, Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
⁷ Division of Infectious Diseases, Department of Medicine, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.
⁸ Gift of Life Donor Program, Philadelphia, Pennsylvania, USA.

Abstract

Antibiotic use in deceased organ donors has not been previously described. In a retrospective cohort of 440 donors, we found 427 (97%) received at least one antibiotic course, 312 (71%) received broad-spectrum antibiotics, and 61 (14%) received potentially redundant antibiotics during their terminal hospitalization, suggesting a need for stewardship.

Keywords: antibiotic; donor; stewardship; transplant.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Anti-Bacterial Agents* / therapeutic use
Humans
Retrospective Studies
Risk Factors
Tissue Donors
Tissue and Organ Procurement*

Substances

Anti-Bacterial Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding