Analysis of the proportion and clinical characteristics of obstructive sleep apnea in women with polycystic ovary syndrome

Rui Yang; Chang Gao; Yizhi Yan; Yongwei Huang; Jianli Wang; Chunmei Zhang; Xiaowei Ma; Nannan Li; Xiaoguo Du; Liqiang Zhang; Ying Wang; Rong Li; Jie Qiao

doi:10.1007/s11325-021-02376-2

Analysis of the proportion and clinical characteristics of obstructive sleep apnea in women with polycystic ovary syndrome

Sleep Breath. 2022 Mar;26(1):497-503. doi: 10.1007/s11325-021-02376-2. Epub 2021 May 19.

Authors

Rui Yang¹, Chang Gao¹, Yizhi Yan¹, Yongwei Huang², Jianli Wang², Chunmei Zhang¹, Xiaowei Ma¹, Nannan Li¹, Xiaoguo Du¹, Liqiang Zhang³, Ying Wang⁴, Rong Li¹, Jie Qiao¹

Affiliations

¹ Reproductive Medical Center, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.
² Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.
³ Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China. byzlq@163.com.
⁴ Reproductive Medical Center, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China. wangying02114@bjmu.edu.cn.

PMID: 34013438
DOI: 10.1007/s11325-021-02376-2

Abstract

Purpose: To investigate the proportion and clinical characteristics of obstructive sleep apnea (OSA) in Chinese patients with polycystic ovarian syndrome (PCOS) through home sleep apnea test (HSAT) and to evaluate the reproductive endocrine and metabolic characteristics in these patients.

Methods: The study was a cross-sectional analysis of infertile PCOS patients who underwent sleep respiratory monitoring between January and December 2019 at Peking University Third Hospital Reproductive Medical Center and respiratory and critical care medicine department. The prevalence of OSA, body mass index (BMI), menstruation, reproductive endocrine, and metabolic characteristics were collected in patients with PCOS. Logistic regression was performed to identify significant relationships among these factors and OSA.

Results: Amont 328 patients with PCOS, the prevalence of OSA was 40% (131/328), and six cases (5%) were severe. Univariate analysis showed that BMI and blood pressure were significantly higher in patients with OSA than in those without OSA (P < 0.05), whereas the anti-Mullerian hormone was lower than that in patients without OSA. In terms of glucose and lipid metabolism, the glycosylated hemoglobin (HbA1c), fasting plasma glucose, and fasting insulin levels were significantly higher in patients with PCOS and comorbid OSA than in those without OSA (all P < 0.05). Patients with OSA also had higher triglyceride, low-density lipoprotein cholesterol, and high-sensitivity C-reactive protein levels and lower high-density lipoprotein cholesterol levels (P < 0.05). Logistic regression analysis revealed that higher BMI, elevated serum testosterone, and decreased high-density lipoprotein cholesterol (HDL-C) are correlated with occurrence of OSA (P < 0.05).

Conclusion: OSA in patients with PCOS was associated with multiple alterations in indexes of reproductive endocrine and metabolic disorders.

Keywords: Endocrine disorder; Metabolic disorder; Obstructive sleep apnea (OSA); Polycystic ovary syndrome (PCOS).

MeSH terms

Adult
China
Cross-Sectional Studies
Endocrine Glands / physiopathology
Female
Humans
Polycystic Ovary Syndrome / complications*
Polycystic Ovary Syndrome / metabolism
Polycystic Ovary Syndrome / physiopathology
Sleep Apnea, Obstructive / complications*
Sleep Apnea, Obstructive / diagnosis*
Sleep Apnea, Obstructive / epidemiology*