Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory

Alexandra Kazanova; Christopher E Rudd

doi:10.1371/journal.pbio.3001272

Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory

PLoS Biol. 2021 May 19;19(5):e3001272. doi: 10.1371/journal.pbio.3001272. eCollection 2021 May.

Authors

Alexandra Kazanova^{1

2}, Christopher E Rudd^{1

2

3}

Affiliations

¹ Division of Immunology-Oncology, Centre de Recherche Hopital Maisonneuve-Rosemont (CR-HMR) Montreal, Canada.
² Department of Microbiology, Infection and Immunology, Faculty of Medicine, Universite de Montreal, Montreal, Canada.
³ Department of Medicine, McGill University Health Center, Montreal, Canada.

Abstract

A recent study shows that programmed cell death 1 ligand (PD-L1) on activated T cells promotes their conversion to suppressive inducible regulatory T cells (iTregs), preferentially from among memory T cells. This new mechanism may normally protect against autoimmunity but is dysregulated in rheumatoid arthritis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Apoptosis
B7-H1 Antigen*
Humans
Ligands
Programmed Cell Death 1 Receptor
T-Lymphocytes, Regulatory*

Substances

B7-H1 Antigen
Ligands
Programmed Cell Death 1 Receptor

Grants and funding

159912/CIHR/Canada