Helical structures are attracting increasing attention owing to their unique typical physical and chemical properties. However, it remains a challenge to construct atypical helical structures at the microscale. This paper proposes a continuous spinning method with a microfluidic-chip-based spinning device to engineer atypical helical microfibers. The strategy causes polymer fluid to form the biomimetic Bulbine torta (BT)-like shape with the aid of the inhomogeneous viscosity rope-coil effect. In particular, the structure parameter of the BT microfibers could be optimized through the synchronous regulation of the microfluidic flow and reaction kinetics, and the obtained microfibers exhibit ultrahigh strain sensitivity, indicating great promise as exceptional candidates for constructing ideal strain sensors. In addition, single- and double-hollow BT microfibers are also prepared by introducing the core flow channel into the microfluidic chip and demonstrate high structural similarity to irregular blood vessels (e.g. varicose veins), which is promising for the actual application of blood vessel tissue engineering.