Modeling the binding of protoporphyrin IX, verteporfin, and chlorin e6 to SARS-CoV-2 proteins

Oskar I Koifman; Natalia Sh Lebedeva; Yury A Gubarev; Mikhail O Koifman

doi:10.1007/s10593-021-02920-8

Modeling the binding of protoporphyrin IX, verteporfin, and chlorin e6 to SARS-CoV-2 proteins

Chem Heterocycl Compd (N Y). 2021;57(4):423-431. doi: 10.1007/s10593-021-02920-8. Epub 2021 May 14.

Authors

Oskar I Koifman^{1

2}, Natalia Sh Lebedeva¹, Yury A Gubarev¹, Mikhail O Koifman²

Affiliations

¹ G. A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, 1 Akademicheskaya St, Ivanovo, 153045 Russia.
² Ivanovo State University of Chemistry and Technology, 7 Sheremetevskii Ave, Ivanovo, 153000 Russia.

Abstract

In this work, we analyze the latest data on the molecular docking of a range of SARS-CoV-2 proteins to protoporphyrin IX, verteporfin, and chlorin e6, as well as consider the prospects for using chlorins and porphyrins as agents for photoinactivation of the SARS2 virus.

Keywords: COVID-19; SARS-CoV-2; chlorin e6; molecular docking; porphyrins; protoporphyrin IX; verteporfin.