A Complementary Strategy to Mitigate Radiation-Induced Cognitive Decline

Navyateja Korimerla; Daniel R Wahl

doi:10.1158/0008-5472.CAN-20-4277

A Complementary Strategy to Mitigate Radiation-Induced Cognitive Decline

Cancer Res. 2021 Apr 1;81(7):1635-1636. doi: 10.1158/0008-5472.CAN-20-4277.

Authors

Navyateja Korimerla¹, Daniel R Wahl²

Affiliations

¹ The Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan.
² The Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan. dwahl@med.umich.edu.

PMID: 34003789
DOI: 10.1158/0008-5472.CAN-20-4277

Abstract

Cranial radiation activates an upstream complement cascade component, C1q, leading to brain injury. Microglia-specific deletion of C1q prevents astrocyte and microglial activation, synaptic loss, neuroinflammation, and cognitive impairment. Therapeutically inhibiting complement activation may help mitigate radiation-induced cognitive decline.See related article by Markarian et al., p. 1732.

Publication types

Comment

MeSH terms

Cognition
Cognitive Dysfunction* / etiology
Cognitive Dysfunction* / prevention & control
Complement C1q*
Humans
Microglia
Neuroglia

Substances

Complement C1q