Avoiding culture shock with the SARS-CoV-2 spike protein

Elife. 2021 May 18:10:e69496. doi: 10.7554/eLife.69496.

Abstract

When culturing SARS-CoV-2 in the laboratory it is vital to avoid deletions in the gene for the spike protein that could affect the interpretation of experiments.

Keywords: COVID-19; SARS-CoV-2; airway organoids; cell culture adaptation; furin cleavage site; infectious disease; microbiology; serine proteases; virus.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • COVID-19*
  • Chlorocebus aethiops
  • Humans
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus*

Substances

  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2