Cold Agglutinin-Mediated Autoimmune Hemolytic Anemia in Association with Antiphospholipid Syndrome

Ram Gelman; Fadi Kharouf; Yuval Ishay; Alexander Gural

doi:10.1159/000516295

Cold Agglutinin-Mediated Autoimmune Hemolytic Anemia in Association with Antiphospholipid Syndrome

Acta Haematol. 2021;144(6):693-697. doi: 10.1159/000516295. Epub 2021 May 17.

Authors

Ram Gelman¹, Fadi Kharouf², Yuval Ishay³, Alexander Gural⁴

Affiliations

¹ Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
² Rheumatology Unit, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
³ Department of Gastroenterology and Liver Diseases, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
⁴ Department of Hematology and Transfusion Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.

PMID: 34000726
DOI: 10.1159/000516295

Abstract

Antiphospholipid syndrome and cold agglutinin-mediated autoimmune hemolytic anemia are 2 distinct immune-mediated hematologic disorders. While no clear association exists between these 2 entities, complement activation is known to occur in both of them. Herein, we report a unique case of cold agglutinin hemolytic anemia in a patient with a known primary antiphospholipid syndrome.

Keywords: Antiphospholipid syndrome; Cold agglutinin; Complement activation; Hemolytic anemia.

Publication types

Case Reports

MeSH terms

Anemia, Hemolytic, Autoimmune / diagnosis*
Anemia, Hemolytic, Autoimmune / etiology
Anemia, Hemolytic, Autoimmune / metabolism
Antibodies, Antiphospholipid / blood
Antiphospholipid Syndrome / complications
Antiphospholipid Syndrome / diagnosis*
Antiphospholipid Syndrome / metabolism
Complement Activation
Cryoglobulins / adverse effects
Electrophoresis
Female
Humans
Immunoglobulin M / adverse effects
Immunoglobulin M / analysis
Middle Aged

Substances

Antibodies, Antiphospholipid
Cryoglobulins
Immunoglobulin M
cold agglutinins