Hyperpolarized 13 C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen-induced Polarization: A Proof-of-Concept in vivo Study

Neil J Stewart; Hitomi Nakano; Shuto Sugai; Mitsushi Tomohiro; Yuki Kase; Yoshiki Uchio; Toru Yamaguchi; Yujirou Matsuo; Tatsuya Naganuma; Norihiko Takeda; Ikuya Nishimura; Hiroshi Hirata; Takuya Hashimoto; Shingo Matsumoto

doi:10.1002/cphc.202100338

Hyperpolarized ¹³ C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen-induced Polarization: A Proof-of-Concept in vivo Study

Chemphyschem. 2021 May 17;22(10):905. doi: 10.1002/cphc.202100338.

Affiliations

¹ Division of Bioengineering & Bioinformatics, Graduate School of Information Science & Technology, Hokkaido University, North 14, West 9, Kita-ku, Sapporo, Hokkaido, 060-0814, Japan.
² Division of Computational Chemistry, Transition State Technology Co. Ltd. 2-16-1 Tokiwadai, Ube, Yamaguchi, 755-8611, Japan.
³ R&D Department, Japan REDOX Ltd. 4-29-49-805 Chiyo, Hakata-ku, Fukuoka, 812-0044, Japan.
⁴ Division of Cardiology and Metabolism, Center for Molecular Medicine, Jichi, Medical University, 3311-1, Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan.
⁵ Chiba Iodine Resource Innovation Center and Department of Chemistry, Graduate School of Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.

PMID: 33998762
DOI: 10.1002/cphc.202100338

Abstract

The front cover artwork is provided by the group of Dr. Neil J. Stewart, Prof. Hiroshi Hirata, and Dr. Shingo Matsumoto (Hokkaido University, Japan) as well as Dr. Takuya Hashimoto (Chiba University, Japan). The image shows hyperpolarized ¹³ C fumarate metabolism to hyperpolarized ¹³ C malate, which is released into the extracellular space in regions of necrotic cell death, where the cell membrane is disrupted. Read the full text of the Article at 10.1002/cphc.202001038.