Hepatomegaly, Elevated Hepatic Enzymes, and Bridging Fibrosis in Patients With Type 1 Diabetes Mellitus

Fahad W Ahmed; Tharaga Kirupakaran; Mara Quante; Andrew Smith

doi:10.7759/cureus.14446

Hepatomegaly, Elevated Hepatic Enzymes, and Bridging Fibrosis in Patients With Type 1 Diabetes Mellitus

Cureus. 2021 Apr 13;13(4):e14446. doi: 10.7759/cureus.14446.

Authors

Fahad W Ahmed¹, Tharaga Kirupakaran², Mara Quante³, Andrew Smith⁴

Affiliations

¹ Diabetes and Endocrinology, University Hospitals Sussex NHS Foundation, Brighton, GBR.
² Diabetes and Endocrinology, Brighton and Sussex Medical School, Brighton, GBR.
³ Histopathology, University Hospitals Sussex NHS Foundation, Brighton, GBR.
⁴ Diabetes, Diabetes Care for You and Sussex Community Foundation NHS Trust, Brighton, GBR.

Abstract

Glycogenic hepatopathy is a rare but reversible condition that includes acute liver dysfunction and hepatomegaly. This occurs due to excessive glycogen accumulation in the hepatocytes. It can occur in patients with poorly controlled type 1 diabetes mellitus. We are reporting a case of a 17-year-old girl who developed liver dysfunction following admission with diabetic ketoacidosis. Ultrasound abdomen confirmed hepatomegaly. However, with improvement in her metabolic control, her liver enzymes and hepatomegaly improved.

Keywords: diabetic ketoacidosis; glycogenic hepatopathy; mauriac syndrome; type 1 diabetes.

Publication types

Case Reports