LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics

Bhupender Yadav; Sonali Pal; Yury Rubstov; Akul Goel; Manoj Garg; Marat Pavlyukov; Amit Kumar Pandey

doi:10.1016/j.omtn.2021.03.018

LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics

Mol Ther Nucleic Acids. 2021 Apr 2:24:728-742. doi: 10.1016/j.omtn.2021.03.018. eCollection 2021 Jun 4.

Authors

Bhupender Yadav¹, Sonali Pal¹, Yury Rubstov^{2

3}, Akul Goel⁴, Manoj Garg⁵, Marat Pavlyukov², Amit Kumar Pandey¹

Affiliations

¹ Amity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, India.
² Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, 117997 Moscow, Russian Federation.
³ Faculty of Biology and Biotechnology, National Research University Higher School of Economics, Vavilova Street 7, 117312 Moscow, Russian Federation.
⁴ La Canada High School, La Canada Flintridge, CA 91011, USA.
⁵ Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University, Uttar Pradesh, Sector 125, Noida 201313, India.

Abstract

Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes.

Keywords: blood-brain barrier; chemoresistance; glioblastoma; long non-coding RNAs; therapeutics.

Publication types

Review