The multidisciplinary care of a woman presenting with lymphoma in pregnancy whose delivery was also complicated by placenta accreta spectrum

Tanya Brooks; Nicola Weale; Francesca Neuberger; Judith Standing; Samreen Siddiq; Joya Pawade

doi:10.1177/1753495X19881873

The multidisciplinary care of a woman presenting with lymphoma in pregnancy whose delivery was also complicated by placenta accreta spectrum

Obstet Med. 2021 Mar;14(1):50-52. doi: 10.1177/1753495X19881873. Epub 2019 Dec 25.

Authors

Tanya Brooks¹, Nicola Weale², Francesca Neuberger², Judith Standing², Samreen Siddiq², Joya Pawade²

Affiliations

¹ Department of Anaesthesia, Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
² North Bristol NHS Trust, Bristol, UK.

Abstract

We report the case of a 44-year-old presenting with breathlessness in her second trimester of pregnancy diagnosed with pulmonary diffuse large B cell lymphoma (DLBCL) which was further complicated by a placenta accreta spectrum (PAS) disorder. In pregnancy, she was treated with rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin and prednisolone, which was associated with neutropenic sepsis requiring admissions to the intensive care unit with respiratory compromise. She safely delivered an infant at 31 weeks but required a hysterectomy at the time for PAS and seven days ventilation on the intensive care unit post-operatively. It is the first case report of DLBCL and PAS in pregnancy.

Keywords: DLBCL; Lymphoma; Non-Hodgkin’s lymphoma; RCHOP; abnormally invasive placenta; accreta; diffuse large B cell lymphoma; placenta accreta spectrum; pregnancy.

Publication types

Case Reports