Stress-induced muscle-to-CNS signaling

Nikolai P Jaschke; Sophie Paehlig; Tilman D Rachner

doi:10.1016/j.tem.2021.05.001

Stress-induced muscle-to-CNS signaling

Trends Endocrinol Metab. 2021 Oct;32(10):750-751. doi: 10.1016/j.tem.2021.05.001. Epub 2021 May 13.

Authors

Nikolai P Jaschke¹, Sophie Paehlig², Tilman D Rachner²

Affiliations

¹ Department of Medicine III, Technische Universität Dresden, Dresden, Germany; Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany. Electronic address: nikolaipirmin.jaschke@uniklinikum-dresden.de.
² Department of Medicine III, Technische Universität Dresden, Dresden, Germany; Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany.

PMID: 33994280
DOI: 10.1016/j.tem.2021.05.001

Abstract

Soluble mediators secreted by skeletal muscles (collectively referred to as myokines) exert systemic effects by signaling to distant organs. Rai et al. have now uncovered a muscle-to-central nervous system (CNS) signaling axis, which is engaged in response to proteostatic stress. These adaptations confer protection against pathological protein accumulation in the CNS, a hallmark of neurodegenerative diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Central Nervous System
Cytokines*
Exercise*
Humans
Muscle, Skeletal
Signal Transduction

Substances

Cytokines