Retrotransposons: Jump to Cancer?

Yangjun Wu; Xiaohua Wu; Shengli Li

doi:10.1016/j.trecan.2021.04.004

Retrotransposons: Jump to Cancer?

Trends Cancer. 2021 Jul;7(7):577-579. doi: 10.1016/j.trecan.2021.04.004. Epub 2021 May 13.

Authors

Yangjun Wu¹, Xiaohua Wu¹, Shengli Li²

Affiliations

¹ Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
² Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: shengli.li@shsmu.edu.cn.

PMID: 33992534
DOI: 10.1016/j.trecan.2021.04.004

Abstract

Retrotransposons have been known as major sources of genomic instability that trigger and promote cancer development. In a recent study, Gu et al. revealed that MPP8 deficiency impeded tumor development through reactivation long interspersed element-1 (LINE-1 or L1) retrotransposons in acute myeloid leukemia (AML), suggesting a tumor-suppressive role for retrotransposons.

Keywords: LINE-1; leukemia; retrotransposon; tumor-suppressor.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Genomic Instability
Humans
Long Interspersed Nucleotide Elements
Neoplasms*
Retroelements*

Substances

Retroelements