The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds

Jianyi Li; Miaomiao Wei; Xin Liu; Shune Xiao; Yuan Cai; Fang Li; Jiao Tian; Fang Qi; Guangchao Xu; Chengliang Deng

doi:10.1016/j.omtn.2021.03.015

The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds

Mol Ther Nucleic Acids. 2021 Apr 1:24:554-578. doi: 10.1016/j.omtn.2021.03.015. eCollection 2021 Jun 4.

Authors

Jianyi Li^{1

2}, Miaomiao Wei^{1

2}, Xin Liu^{1

2}, Shune Xiao^{1

2}, Yuan Cai¹, Fang Li¹, Jiao Tian^{1

2}, Fang Qi^{1

2}, Guangchao Xu^{1

2}, Chengliang Deng^{1

2}

Affiliations

¹ Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, People's Republic of China.
² Collaborative Innovation Center of Tissue Injury Repair and Regenerative Medicine Co-sponsored by Province and Ministry, Affiliated Zunyi Medical University, Zunyi, Guizhou 563000, People's Republic of China.

Abstract

Chronic diabetic wounds affect the quality of life of patients, resulting in significant social and economic burdens on both individuals and the health care system. Although treatment methods for chronic diabetic wounds have been explored, there remains a lack of effective treatment strategies; therefore, alternative strategies must be explored. Recently, the abnormal expression of non-coding RNA in diabetic wounds has received widespread attention since it is an important factor in the development of diabetic wounds. This article reviews the regulatory role of three common non-coding RNAs (microRNA [miRNA], long non-coding RNA [lncRNA], and circular RNA [circRNA]) in diabetic wounds and discusses the diagnosis, treatment potential, and challenges of non-coding RNA in diabetic wounds. This article provides insights into new strategies for diabetic wound diagnosis and treatment at the genetic and molecular levels.

Keywords: circRNA; diabetic wound; lncRNA; miRNA; non-coding RNA.

Publication types

Review