Polygenic Liability and Recurrence of Depression in Patients With First-Onset Depression Treated in Hospital-Based Settings

Katherine L Musliner; Esben Agerbo; Bjarni J Vilhjálmsson; Clara Albiñana; Thomas D Als; Søren D Østergaard; Preben B Mortensen

doi:10.1001/jamapsychiatry.2021.0701

Polygenic Liability and Recurrence of Depression in Patients With First-Onset Depression Treated in Hospital-Based Settings

JAMA Psychiatry. 2021 Jul 1;78(7):792-795. doi: 10.1001/jamapsychiatry.2021.0701.

Authors

Katherine L Musliner^{1

2}, Esben Agerbo^{1

2

3}, Bjarni J Vilhjálmsson¹, Clara Albiñana¹, Thomas D Als^{2

4}, Søren D Østergaard^{5

6}, Preben B Mortensen^{1

2

3}

Affiliations

¹ National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark.
² The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
³ Centre for Integrated Register-Based Research at Aarhus University (CIRRAU), Aarhus, Denmark.
⁴ Department of Biomedicine, Aarhus University, Aarhus, Denmark.
⁵ Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
⁶ Department of Affective Disorders, Aarhus University Hospital-Psychiatry, Aarhus, Denmark.

Abstract

This cohort study examines the association of polygenic risk score for major depression with risk of recurrence in individuals diagnosed with unipolar depression in hospital-based settings and estimates the absolute risk of recurrence based on polygenic risk.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Case-Control Studies
Child
Denmark / epidemiology
Depressive Disorder, Major / epidemiology*
Depressive Disorder, Major / genetics*
Disease Progression*
Emergency Services, Psychiatric / statistics & numerical data
Female
Follow-Up Studies
Hospitals, Psychiatric / statistics & numerical data
Humans
Male
Multifactorial Inheritance / genetics*
Recurrence
Risk
Young Adult

Grants and funding

U01 MH094432/MH/NIMH NIH HHS/United States