I SPI1 something needed for B cells

Lara Wahlster; Vijay G Sankaran

doi:10.1084/jem.20210572

I SPI1 something needed for B cells

J Exp Med. 2021 Jul 5;218(7):e20210572. doi: 10.1084/jem.20210572. Epub 2021 May 12.

Authors

Lara Wahlster^{1

2

3}, Vijay G Sankaran^{1

2

3}

Affiliations

¹ Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
² Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
³ Broad Institute of MIT and Harvard, Cambridge, MA.

Abstract

In this issue, Le Coz et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201750) describe a novel immunodeficiency syndrome caused by mutations in SPI1. Through a series of in-depth studies, the authors provide insights into how SPI1 affects blood lineage specification, highlighting the important role of master transcription factors as cellular fate determinants.

I SPI1 something needed for B cells

Authors

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Abstract

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Grants and funding