PEGylated AIEgen molecular probe for hypoxia-mediated tumor imaging and photodynamic therapy

Chem Commun (Camb). 2021 May 11;57(38):4710-4713. doi: 10.1039/d1cc00967b.

Abstract

We report a novel PEGylated aggregation-induced emission luminogen (AIEgen) molecular probe for hypoxia-mediated tumor imaging and photodynamic therapy by linking a PEG chain to the AIE-active photosensitizer via a hypoxia-sensitive azo group.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Proliferation / drug effects
  • Density Functional Theory
  • Drug Screening Assays, Antitumor
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / pharmacology*
  • Hep G2 Cells
  • Humans
  • Hypoxia / drug therapy*
  • Liver Neoplasms, Experimental / diagnostic imaging
  • Liver Neoplasms, Experimental / drug therapy
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Molecular Structure
  • Optical Imaging*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / pharmacology*

Substances

  • Antineoplastic Agents
  • Fluorescent Dyes
  • Photosensitizing Agents
  • Polyethylene Glycols