Abstract
We report a novel PEGylated aggregation-induced emission luminogen (AIEgen) molecular probe for hypoxia-mediated tumor imaging and photodynamic therapy by linking a PEG chain to the AIE-active photosensitizer via a hypoxia-sensitive azo group.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Density Functional Theory
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Drug Screening Assays, Antitumor
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / pharmacology*
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Hep G2 Cells
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Humans
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Hypoxia / drug therapy*
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Liver Neoplasms, Experimental / diagnostic imaging
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Liver Neoplasms, Experimental / drug therapy
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Molecular Structure
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Optical Imaging*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology*
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Polyethylene Glycols / chemistry
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Polyethylene Glycols / pharmacology*
Substances
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Antineoplastic Agents
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Fluorescent Dyes
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Photosensitizing Agents
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Polyethylene Glycols