Malignant Peripheral Nerve Sheath Tumor of the Cerebellar Hemisphere: An Unusual Location and Multiple Intracranial Parenchyma Metastases

Jiangwei Ding; Lei Wang; Haibiao Zhao; Feng Wang; Tao Sun

doi:10.7759/cureus.14373

Malignant Peripheral Nerve Sheath Tumor of the Cerebellar Hemisphere: An Unusual Location and Multiple Intracranial Parenchyma Metastases

Cureus. 2021 Apr 8;13(4):e14373. doi: 10.7759/cureus.14373.

Authors

Jiangwei Ding¹, Lei Wang², Haibiao Zhao³, Feng Wang⁴, Tao Sun⁵

Affiliations

¹ Department of Neurosurgery, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, CHN.
² Department of Neurosurgery, Ningxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, General Hospital of Ningxia Medical University, Yinchuan, CHN.
³ Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, CHN.
⁴ Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, CHN.
⁵ Department of Neurosurgery, Ningxia Key Laboratory of Cerebrocranial Disease, General Hospital of Ningxia Medical University, Yinchuan, CHN.

Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue malignancies that can occur in any part of the body. The most common sites are the proximal limbs and trunk. Intracranial MPNSTs are rare; most originate from the auditory, trigeminal, and other cranial nerves, and occurrence within the brain parenchyma is rarer. Here, we describe a malignant peripheral schwannoma in the cerebellar hemisphere of the brain parenchyma. To our knowledge, this is the first case of brain parenchymal metastasis of an MPNST. We observed no effects on the tumor after the application of multiple chemotherapy drugs; thereafter, we explored the literature surrounding the condition.

Keywords: brain parenchyma metastases; cerebellar mpnst; malignant intracerebral nerve sheath tumors; malignant peripheral nerve sheath tumors.

Publication types

Case Reports