Integrated nanomaterials for non-invasive photothermal therapy of rheumatoid arthritis

Drug Discov Today. 2021 Oct;26(10):2315-2328. doi: 10.1016/j.drudis.2021.04.026. Epub 2021 May 5.

Abstract

Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease that causes swelling, redness, and arthralgia of multiple joints. Despite significant research and development on the treatment modalities for RA, there is still no established effective treatment option for eradicating joint damage and inflammation. In recent years, photothermal therapy (PTT) has emerged as a practical approach to treat RA. In this review, we outline various factors that affect the effective treatment of RA. Moreover, we discuss various PTT-based nanomaterials that can be used to treat RA.

Keywords: Inflammation; Nanomaterials; Near-infrared light; Photothermal therapy; Rheumatoid arthritis.

Publication types

  • Review

MeSH terms

  • Animals
  • Arthralgia / etiology
  • Arthralgia / therapy
  • Arthritis, Rheumatoid / physiopathology
  • Arthritis, Rheumatoid / therapy*
  • Humans
  • Inflammation / etiology
  • Inflammation / pathology
  • Inflammation / therapy
  • Nanostructures*
  • Photothermal Therapy / methods*