Adhesion G protein-coupled receptors in glioblastoma

Gabriele Stephan; Niklas Ravn-Boess; Dimitris G Placantonakis

doi:10.1093/noajnl/vdab046

Adhesion G protein-coupled receptors in glioblastoma

Neurooncol Adv. 2021 Mar 23;3(1):vdab046. doi: 10.1093/noajnl/vdab046. eCollection 2021 Jan-Dec.

Authors

Gabriele Stephan¹, Niklas Ravn-Boess¹, Dimitris G Placantonakis^{1

2

3

4

5}

Affiliations

¹ Department of Neurosurgery, NYU Grossman School of Medicine, New York, New York, USA.
² Kimmel Center for Stem Cell Biology, NYU Grossman School of Medicine, New York, New York, USA.
³ Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, New York, USA.
⁴ Brain and Spine Tumor Center, NYU Grossman School of Medicine, New York, New York, USA.
⁵ Neuroscience Institute, NYU Grossman School of Medicine, New York, New York, USA.

Abstract

Background: Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma.

Methods: Here, we discuss the basic biology of adhesion GPCRs and review in detail specific members of the receptor family with known functions in glioblastoma. Finally, we discuss the potential use of adhesion GPCRs as novel treatment targets in neuro-oncology.

Keywords: G protein-coupled receptor; adhesion GPCR; glioblastoma.

Publication types

Review

Abstract

Publication types

Grants and funding