The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway

Maonan Wang; Manli Dai; Dan Wang; Ting Tang; Fang Xiong; Bo Xiang; Ming Zhou; Xiaoling Li; Yong Li; Wei Xiong; Guiyuan Li; Zhaoyang Zeng; Can Guo

doi:10.1016/j.canlet.2021.04.025

The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway

Cancer Lett. 2021 Aug 1:512:60-72. doi: 10.1016/j.canlet.2021.04.025. Epub 2021 May 2.

Authors

Maonan Wang¹, Manli Dai², Dan Wang², Ting Tang², Fang Xiong³, Bo Xiang², Ming Zhou³, Xiaoling Li³, Yong Li⁴, Wei Xiong¹, Guiyuan Li¹, Zhaoyang Zeng⁵, Can Guo⁶

Affiliations

¹ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
² NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
³ Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
⁴ Department of Medicine, Comprehensive Cancer Center Baylor College of Medicine, Houston, TX, USA.
⁵ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: zengzhaoyang@csu.edu.cn.
⁶ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: guocde@csu.edu.cn.

PMID: 33951538
DOI: 10.1016/j.canlet.2021.04.025

Abstract

Long noncoding RNAs (lncRNAs) play an important role in the regulation of gene expression and are involved in several pathological responses. However, many important lncRNAs in breast cancer have not been identified and their expression levels and functions in breast cancer remain unknown. In this study, the lncRNA apoptosis-associated transcript in bladder cancer (AATBC) was found to be significantly highly expressed in breast cancer patients. In vitro and in vivo experiments indicated that AATBC promoted breast cancer metastasis. Further studies revealed that AATBC activated the YAP1/Hippo signaling pathway through the AATBC-YBX1-MST1 axis. This is also an important supplement to the composition of the YAP1/Hippo signaling pathway. The model of "AATBC-YAP1" may bring a new dawn to the treatment of breast cancer.

Keywords: Apoptosis-associated transcript in bladder cancer; LncRNA; MST1; Nucleic localization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / genetics*
Breast Neoplasms / pathology
Female
Hippo Signaling Pathway
Humans
Protein Serine-Threonine Kinases / metabolism*
RNA, Long Noncoding / metabolism*
Signal Transduction
Transfection
Y-Box-Binding Protein 1 / metabolism*

Substances

RNA, Long Noncoding
Y-Box-Binding Protein 1
YBX1 protein, human
Protein Serine-Threonine Kinases