B-cell acute lymphoblastic leukemia-related microRNAs: uncovering their diverse and special roles

Mengqi Lv; Shicong Zhu; Hongling Peng; Zhao Cheng; Guangsen Zhang; Zhihua Wang

B-cell acute lymphoblastic leukemia-related microRNAs: uncovering their diverse and special roles

Am J Cancer Res. 2021 Apr 15;11(4):1104-1120. eCollection 2021.

Authors

Mengqi Lv^{1

2}, Shicong Zhu³, Hongling Peng^{1

2}, Zhao Cheng^{1

2}, Guangsen Zhang^{1

2}, Zhihua Wang^{1

2}

Affiliations

¹ Department of Hematology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
² Institute of Molecular Hematology, Central South University Changsha, Hunan, China.
³ Department of Geriatrics, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.

PMID: 33948348
PMCID: PMC8085864

Abstract

B-cell acute lymphoblastic leukemia (B-ALL) is a common type of hematologic malignancy characterized by the uncontrolled growth of immature B lymphocytes. Genomics, transcriptomics, and proteomics at different levels contribute to early diagnosis and can thereby provide better treatment for cancer. MicroRNAs (miRNAs) are conducive to the diagnosis and treatment of patients with B-ALL. Moreover, evidence suggests that runaway miRNAs and exosomes containing miRNA may be involved in the occurrence of B-ALL, which can then be used as potential biomarkers. This review summarizes the role of miRNAs in the pathogenesis, diagnosis, prognosis, and treatment of B-ALL.

Keywords: B-cell acute lymphoblastic leukemia; MicroRNA; biomarker; diagnosis; exosome; treatment.

Publication types

Review