Commiphoranes K-O, New Terpenoids from Resina Commiphora and Their Anti-Inflammatory Activities

Chem Biodivers. 2021 Jul;18(7):e2100265. doi: 10.1002/cbdv.202100265. Epub 2021 Jun 2.

Abstract

Commiphorane K (1), a new dinorditerpenoid, commiphoranes L-N (2-4), three new germacrane-type sesquiterpenoids, and commiphorane O (5), one new guaiane-type sesquiterpenoid, were isolated from Resina Commiphora. Their structures were characterized by spectroscopic and computational methods. In particular, the structure of 4 was confirmed by X-ray crystallography. Compounds 2-5 were evaluated for their anti-inflammatory activities. The result shows that compound 2 suppresses lipopolysaccharide (LPS)-stimulated production of TNF-α in RAW264.7 cells in a dose-dependent manner.

Keywords: Resina Commiphora; anti-inflammation; dinorditerpenoid; sesquiterpenoids.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Cell Survival / drug effects
  • Commiphora / chemistry*
  • Crystallography, X-Ray
  • Dose-Response Relationship, Drug
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • Lipopolysaccharides / antagonists & inhibitors
  • Lipopolysaccharides / pharmacology
  • Mice
  • Models, Molecular
  • Molecular Structure
  • RAW 264.7 Cells
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Tumor Necrosis Factor-alpha / biosynthesis

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Lipopolysaccharides
  • Tumor Necrosis Factor-alpha