Leprosy as a Diagnostic Challenge in the United States

Skinmed. 2021 Apr 1;19(2):137-141. eCollection 2021.

Abstract

A 63-year-old woman from Central Florida presented to an outside clinic with a 2-year history of a progressive, asymptomatic cutaneous eruption and arthralgias. Her past medical history was significant for reported seronegative rheumatoid arthritis, for which adalimumab, methotrexate, and low-dose prednisone therapy were initiated 5 years prior. The skin eruption occurred shortly after a 4-week hospitalization during which these medications were withheld. At her initial outside evaluation, a biopsy was performed and interpreted as subacute cutaneous lupus erythematosus (SCLE). She was treated with hydroxychloroquine without improvement. A repeat biopsy was reported as consistent with interstitial granulomatous dermatitis (IGD). There was no improvement with potent topical corticosteroids.

Publication types

  • Case Reports

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Dermatitis / complications
  • Dermatitis / diagnosis
  • Female
  • Florida
  • Glucocorticoids / therapeutic use*
  • Humans
  • Lupus Erythematosus, Cutaneous / diagnosis*
  • Lupus Erythematosus, Cutaneous / drug therapy*
  • Middle Aged
  • Prednisolone / therapeutic use

Substances

  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Prednisolone