Nanotechnology-based approaches for emerging and re-emerging viruses: Special emphasis on COVID-19

Muthupandian Saravanan; Ebrahim Mostafavi; Savariar Vincent; Hadush Negash; Rajapriya Andavar; Venkatesan Perumal; Namas Chandra; Selvaraju Narayanasamy; Kalishwaralal Kalimuthu; Hamed Barabadi

doi:10.1016/j.micpath.2021.104908

Nanotechnology-based approaches for emerging and re-emerging viruses: Special emphasis on COVID-19

Microb Pathog. 2021 Jul:156:104908. doi: 10.1016/j.micpath.2021.104908. Epub 2021 Apr 28.

Affiliations

¹ Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, College of Health Sciences, Mekelle University, P.O.BOX-1871, Mekelle, Ethiopia; Antimicrobial resistance and Nanomedicine Laboratory, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 600077, India. Electronic address: bioinfosaran@gmail.com.
² Stanford Cardiovascular Institute, Stanford, CA, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Chemical Engineering, Northeastern University, Boston, MA, USA. Electronic address: ebimsv@stanford.edu.
³ Centre for Environmental Research and Development (CERD), Loyola Institute of Frontier Energy, Loyola College, Chennai, 600 034, India.
⁴ Department of Medical Microbiology, Institute of Biomedical Sciences, College of Medicine and Health Science, Adigrat University, Adigrat, Ethiopia.
⁵ Department of Nanoscience and Technology, Bharathiar University, Coimbatore, India.
⁶ Center for Injury Biomechanics, Materials, and Medicine, Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ,07102, USA.
⁷ Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.
⁸ Department of Surgery, School of Medicine, University of Pittsburgh, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.
⁹ Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: barabadi@sbmu.ac.ir.

Abstract

In recent decades, the major concern of emerging and re-emerging viral diseases has become an increasingly important area of public health concern, and it is of significance to anticipate future pandemic that would inevitably threaten human lives. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged virus that causes mild to severe pneumonia. Coronavirus disease (COVID-19) became a very much concerned issue worldwide after its super-spread across the globe and emerging viral diseases have not got specific and reliable diagnostic and treatments. As the COVID-19 pandemic brings about a massive life-loss across the globe, there is an unmet need to discover a promising and typically effective diagnosis and treatment to prevent super-spreading and mortality from being decreased or even eliminated. This study was carried out to overview nanotechnology-based diagnostic and treatment approaches for emerging and re-emerging viruses with the current treatment of the disease and shed light on nanotechnology's remarkable potential to provide more effective treatment and prevention to a special focus on recently emerged coronavirus.

Keywords: COVID-19; Coronavirus; Inorganic nanoparticles; Lipid nanoparticles; Nanotherapeutics; Polymeric nanoparticles.

Publication types

Review

MeSH terms

COVID-19*
Humans
Nanotechnology
Pandemics* / prevention & control
Public Health
SARS-CoV-2