Role of the NLRP3 inflammasome in asthma: Relationship with neutrophilic inflammation, obesity, and therapeutic options

J Allergy Clin Immunol. 2021 Jun;147(6):2060-2062. doi: 10.1016/j.jaci.2021.04.022. Epub 2021 Apr 28.

Authors

Evan J Williams¹, Netsanet A Negewo¹, Katherine J Baines²

Affiliations

¹ Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, Callaghan, Australia.
² Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, Callaghan, Australia. Electronic address: katherine.baines@newcastle.edu.au.

PMID: 33932467
DOI: 10.1016/j.jaci.2021.04.022

No abstract available

Keywords: Asthma; NLRP3 inflammasome; neutrophil extracellular traps; neutrophils; obesity.

Publication types

Editorial

MeSH terms

Asthma / diagnosis
Asthma / etiology*
Asthma / metabolism*
Asthma / therapy
Clinical Decision-Making
Disease Management
Disease Susceptibility*
Humans
Inflammasomes / metabolism*
Inflammation / complications
Inflammation / immunology
Inflammation / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*
Neutrophils / immunology
Neutrophils / metabolism
Obesity / complications

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein