Pathophysiological role of prostaglandin E synthases in liver diseases

Delong Xu; Jie Cai; Zhi-Kang Wan; Hang Gao; Ying Sun

doi:10.1016/j.prostaglandins.2021.106552

Pathophysiological role of prostaglandin E synthases in liver diseases

Prostaglandins Other Lipid Mediat. 2021 Jun:154:106552. doi: 10.1016/j.prostaglandins.2021.106552. Epub 2021 Apr 27.

Authors

Delong Xu¹, Jie Cai¹, Zhi-Kang Wan¹, Hang Gao¹, Ying Sun²

Affiliations

¹ Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China.
² Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China. Electronic address: sunyingwyo@163.com.

PMID: 33930567
DOI: 10.1016/j.prostaglandins.2021.106552

Abstract

Prostaglandin E synthases (PGESs) convert cyclooxygenase (COX)-derived prostaglandin H₂ (PGH₂) into prostaglandin E₂ (PGE₂) and comprise at least three types of structurally and biologically distinct enzymes. Two of these, namely microsomal prostaglandin E synthase-1 (mPGES-1) and mPGES-2, are membrane-bound enzymes. mPGES-1 is an inflammation-inducible enzyme that converts PGH₂ into PGE₂. mPGES-2 is a bifunctional enzyme that generally forms a complex with haem in the presence of glutathione. This enzyme can metabolise PGH₂ into malondialdehyde and can produce PGE₂ after its separation from haem. In this review, we discuss the role of PGESs, particularly mPGES-1 and mPGES-2, in the pathogenesis of liver diseases. A better understanding of the roles of PGESs in liver disease may aid in the development of treatments for patients with liver diseases.

Keywords: Liver; Microsomal prostaglandin E synthase-1; Prostaglandin E synthases; Prostaglandin E(2); mPGES-2.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Prostaglandin-E Synthases*

Substances

Prostaglandin-E Synthases